标题： Design of bright near-infrared-emitting quantum dots capped with different stabilizing ligands for tumor targeting
作者： Liu, XJ (Liu, Xijing); Zhou, PJ (Zhou, Peijiang); Liu, HY (Liu, Hongyu); Zhan, HJ (Zhan, Hongju); Zhang, Q (Zhang, Qiang); Zhao, YN (Zhao, Yanan); Chen, Y (Chen, Yun)
来源出版物：RSC ADVANCES 卷：8期：8 页码:4221-4229 DOI：10.1039/c7ra10824a 出版年： 2018
摘要： In this study, a facile formulation of near-infrared (NIR)-emitting CdHgTe/CdS/CdZnS quantum dots (QDs) was fabricated and coated with three different thiol ligands, N-acetyl-L-cysteine (NAC), 3-mercaptopropionic acid (MPA) and thioglycolic acid (TGA). The optical properties, morphology, hydrodynamic diameters, structure and surface chemistries of the developed QDs were comprehensively assessed. As a therapeutic drug, NAC provides excellent biocompatibility and anti-oxidant activity both in vitro and in vivo. Given their core-shell-shell structure, the QDs induced no toxicity in living bodies even at a concentration of 20 mg kg(-1). Compared with NAC-capped QDs, TGA- and MPA-capped QDs demonstrated poor tumor-targeting capabilities because of their larger hydrodynamic diameters and inferior biocompatibility. Furthermore, the use of different stabilizing ligands resulted in various major changes in organ biodistribution and clearance from the body. In terms of rapid metabolization through renal clearance, the NAC-capped core-shell-shell QDs will be an alternative probe in cellular metabolism studies and image-guided surgery for tumor targeting and removal.
扩展关键词： MICROWAVE SYNTHESIS; OPTICAL-PROPERTIES; CDTE NANOCRYSTALS; CADMIUM IONS; HIGH-QUALITY; NANOPARTICLES; CANCER; CELLS; PHOTOLUMINESCENCE; CYTOTOXICITY
通讯作者地址：Zhou, PJ (通讯作者),Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci, Wuhan 430079, Hubei, Peoples R China.
Chen, Y (通讯作者),Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Hubei, Peoples R China.
[Liu, Xijing; Zhou, Peijiang; Liu, Hongyu] Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Sch Resource & Environm Sci, Wuhan 430079, Hubei, Peoples R China.
[Zhan, Hongju] Jingchu Univ Technol, Jingmen 448000, Peoples R China.
[Zhang, Qiang; Zhao, Yanan; Chen, Yun] Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Hubei, Peoples R China.
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